What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in the body, essential for energy metabolism and cellular repair. Research shows that supporting NAD+ levels is generally well tolerated in healthy adults and effectively raises NAD+-related markers in the blood (1,2). Clinical studies across a range of populations โ including older adults and those with chronic health conditions โ have observed potential benefits such as improved insulin sensitivity, reduced anxiety symptoms, and better post-exercise heart rate recovery (3). Some trials have also shown measurable improvements in metabolic markers, including blood glucose response, after short-term supplementation (2).
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A look at peer-reviewed human clinical trials examining NAD+ and its precursors.
A randomized, double-blind, placebo-controlled crossover trial found that sustained supplementation with an NAD+ precursor was well tolerated in middle-aged and older adults and effectively raised NAD+ metabolism markers. The study also identified blood pressure and arterial stiffness as promising areas for future cardiovascular research related to NAD+ support.
In a randomized, triple-blind, placebo-controlled crossover pilot study, healthy middle-aged adults given an NAD+ precursor combination saw a significant rise in NAD-related blood markers compared to placebo, along with measurable reductions in blood glucose, suggesting improved metabolic response over the short supplementation period.
A systematic review of 10 randomized clinical trials spanning conditions such as chronic fatigue, aging, and Parkinson’s disease found NAD+ and its precursors were generally well tolerated, with individual trials reporting benefits including reduced anxiety symptoms, improved post-exercise heart rate recovery, and increased muscle insulin sensitivity.
1. Martens et al., “Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults,” Nature Communications, 2018.
2. Pilot randomized, triple-blind, placebo-controlled crossover trial of an NAD+ precursor combination in healthy middle-aged adults, PMC.
3. Systematic review of 10 randomized clinical trials evaluating NAD+ supplementation across multiple clinical conditions, American Journal of Physiology-Endocrinology and Metabolism, 2023.
Research findings vary by study design and population. Individual results with NAD+ therapy may differ from those observed in clinical research.
The statements on this page have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
NAD+ injectable therapy is compounded by a licensed pharmacy. Compounded medications, including NAD+, are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality.
This treatment is available only following an online medical evaluation. A licensed provider will determine which dosing plan, if any, is appropriate for you based on your individual health history. All dosing plans are not automatically appropriate for every patient and remain subject to provider evaluation and approval.
Individual results and experiences with NAD+ therapy vary, and outcomes are not guaranteed.
The most commonly reported side effect is irritation of the area where the injection is administered.โ If this occurs, consider changing placement on the body or use injections less often.
If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
| Therapy Size | 500mg (2+ Weeks), 1000mg (4+ Weeks), 2000mg (8+ Weeks) |
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